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I was diagosed with inoperable NSCLC in March 11. I am taking Iressa as a first line treatment. I had no side effects for 2 weeks then the rash on my face started. I am female so was able to cover this with makeup. My skin became very dry too but moisturizers helped. I had tummy cramps which started at the same time, no diarrhea initially as I was still taking morphine from unsuccessful surgery. After 6 weeks I had my first scan. My tumor that had been 11cms was now 8.5cms, this was a pleasant surprise as I was told the Iressa would not shrink it but just stop it from growing. Since stopping the morphine I now suffer from tummy cramps and diarrhea most days, usually at night. I feel it is a small price to pay. I take Imodium which helps.
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My sister was diagnosed with lungs cancer about four years ago. It was a real shock for the whole family, but we soon recovered from it as we needed to support her and make her struggle with the disease. We have visited many doctors and all of them prescribed strange unconventional drugs, we even tried some of them, but they provided no effect and my sister's condition was growing worse. One day we visited a doctor in Chicago and he advised us to try Iressa as a medication aimed exactly at lungs cancer. He was so enthusiastic about the drug that my sister let me talk her into trying it. Iressa really helped her! She's much better now and she started believing in recovery! Great med, thanks to its inventors.
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May interrupt therapy briefly (up to 14 days) if adverse dermatologic reactions or poorly tolerated diarrhea (sometimes with dehydration) occurs.
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The tumor growth models for each tumor group were derived in a sequential manner by fitting to the control groups first, and then fitting to the gefitinib-treated groups.
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Taking into consideration that all the patients in our research were adenocarcinoma, the well known type of lung cancer that can get maximum benefit from TKIs therapy, and the low abundance of DNA in body fluid, the results indicated that there might still be false negative mutations in these samples.
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Canadian labeling: Additional contraindications (not in US labeling): Coadministration with terfenadine, astemizole, or cisapride (each drug is no longer marketed in Canada).
The trial was completed in June 2006 but no published article summarizing the findings was identified.
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Cancer is a disease of the and as more is learned about cancer tumors, the more we are finding that each tumor has its own set of genetic changes.
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You can zoom by holding shift while using left click and drag.
This regimen causes more side effects than pemetrexed, the newer second-line drug.
The INSPIRE trial () randomly assigned 633 patients with advanced nonsquamous NSCLC to receive either first-line chemotherapy with cisplatin and pemetrexed or to cisplatin and pemetrexed with the addition of necitumumab (800 mg on day 1 and 8 of each cycle).
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Treatment and Outcomes for Metastatic Sebaceous Cell Carcinoma of the Eyelid.
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EGFR-TKI results in a decreasing in tumor diameter, and improvement of symptoms ().
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Results Of the 552 patients, 27 (4.
In this review, we discuss the clinical data supporting the use and practical aspects of management of patients on epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors.
Radical radiation is used as the sole procedure in stage I and some stage II patients who have adequate lung function but, for medical or other reasons, cannot be treated with surgery.
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Ascites-derived pancreatic ductal adenocarcinoma primary cell cultures as a platform for personalised medicine.
Karnebeek at the Division of Biochemical Diseases, Rm.
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CYP3A4 inhibitors: Potential pharmacokinetic interaction (decreased gefitinib metabolism, increased plasma gefitinib concentrations).
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The majority of ILD-type events reported were from patients of Asian ethnicity and the ILD incidence among patients of Asian ethnicity receiving IRESSA therapy and placebo was similar, approximately 3% and 4% respectively.
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Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas.
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Integration of targeted therapy in the management of locally advanced, unresectable non-small-cell lung cancer.
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